FP6 - NMP4-CT-2003-505211 BIOSCOPE - Self-reporting biological nanosystems to study and control bio-molecular mechanisms on the single molecule level

Contacts
Website: www.bioscope.fkem1.lu.se/index.asp




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Biological Conversion : Biotechnology : Nanotechnology : Nanotechnology and Materials

Type of Project	STREP
Contract No	FP6 - NMP4-CT-2003-505211
Total Cost	2,120 KEuro
EC Contribution	1,880 KEuro
Start Date	1-6-2004
Duration	48 Months

Abstract

This project aims to develop new nano-scale tools allowing unprecedented insight into bio-molecular mechanisms at biological interfaces on the scale of single molecules. The key element in the strategy is to involve the bimolecular system itself as part of the baroscopic instrument which in various ways reports to the out-side world about its current local state. The proejct benefits from the synergy between recent advances in nano technology and the adaptive dynamic behaviour of many natural and artificial biological systems, which change their structure, physical chemical state and properties as a reaction to the local baroscopic environment.

The objectives are

• To develop instrumentation and methods for manipulation of enzymes and enzyme activity at the scale-scale providing insight into the bimolecular mechanisms on a single molecule level.
• To develop novel forms of integration, at the level-level, of enzymes and non-biological systems such as nano-particles, artificial membranes, electrical field or force field traps.
• To confine several enzymes to surfaces of nanoparticles or membranes on a less than 10 nm scale in order to achieve a self-organized assembly with concerted as well as controllable bioaction superior to the simple sum of the same individual enzymes.

The impact of the project is expected to be seen in the long-term not only by providing new tools for the scientist, but also by making possible the rational design of new enzymes (and other proteins) based on their bio-molecular mechanism. The knowledge-base provided as a result of this work will allow researchers and industries to move from design of bimolecular systems based on end-state global properties, which is just one, some times distant, consequence of the true bimolecular mechanism.

The project will provide new leads for major break-through in analyses and syntheses, which in turn will lead to the creation of several new SMEs.

Coordinator

Lund University, Physical Chemistry 1, Sweden

Partners

• Novozymes A/S, Denmark
• Biochemijos Institutas, Lithuania
• Kobenhavns Universitet, Denmark
• The University of Liverpool, United Kingdom
• Syddansk Universitet, Denmark
• Stichting Katholieke Universiteit, Netherlands
• Ludwig-Maximilians-Universitaet Muenchen, Germany
• Katholieke Universiteit Leuven, Belgium

Contacts

Contact

• Tommy NYLANDER / University of Lund Center for Chemistry and Chemical Engineering / SWEDEN