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FP5
Theme 1 - Key Action 3 - The "Cell Factory"
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Website:
www.cordis.lu/fp5/home.html


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Background Information


Objectives and deliverables
The socio-economic objective of this key action is the integration of
innovative research and technologies with the exploitation of advances
made in life sciences and technologies, particularly in the fields of
health, environment, food, agriculture, agro-industries and high
value-added products, by Community's enterprises and by the public sector.
The problem solving approach of this key action will give particular
attention to strengthening European industrial competitiveness by
improving the potential for creation of small research-based biotechnology
firms and entrepreneurial initiatives. These knowledge-based new
industries correspond to a reservoir of industrial competitiveness,
scientific and technological innovation, opportunities for investors, and
jobs creation, which is still under exploited in Europe. The challenge is
to integrate the whole range of innovation, from advanced research,
through technological development up to demonstration, providing an
environment in which scientific results could rapidly be exploited and
transformed into products and processes of interest to the society. This
key action will therefore mobilise the necessary operators (scientists,
industrialists, venture capitalists, consumer and patient's associations)
to address the following objectives in a coordinated and convergent way:
- Innovative technologies mobilising mission oriented research. New
knowledge will be generated on the functioning of cells as biological
factories, through contributions of advanced RTD such as genomics,
proteomics, combinatorial biochemistry, high-throughput screening,
nanobiotechnology, structural biology, molecular evolution,
bioinformatics, and biochemical engineering. These technologies will
provide new processes and molecules, for implementing the priorities
given in the work programme.
- Exploitation of RTD results. Efficient risk capital markets, creation
and development of high-tech SMEs, and promoting the dialogue of
technology producers with technology users are crucial for linking
research to socio-economic needs, leading to future wealth and job
creation. The challenge is therefore to set up a nurturing environment
for the development of established bio-industries and a new generation
of European entrepreneurs to start up and flourish.
- Linking research and technologies to exploitation of results. To
attain the expected deliverables of the key action, scientific and
technological excellence is necessary but not sufficient, and should be
closely linked to firm commitment for knowledge transfer and convincing
exploitation.
Towards the anticipated deliverable consisting in developing established
bioindustries, triggering the creation and sustaining the growth rate of
new biotech research-based industries, the European players should be
mobilised to seize those opportunities in priority areas that include:
- the development of new and improved health related processes and
products from living cells and biomolecules, particularly towards
improved therapeutics, new antibiotics, anticancer therapies, in vitro
alternative tests, diagnostics tests, innovative technologies for
biological production and novel targets for drug discovery.
- the development of cleaner technologies and the improvement of
bioremediation and waste biotreatment processes, particularly towards
environmental friendly products and processes, recycling and/or
biodegradation of wastes and industrial by-products, bioassays to
monitor the effects of toxic chemicals on biological systems, and
methods and strategies for safe introduction, use, monitoring and
tracing of GMOs. Several of these activities are highly relevant to
underpinning and future development of policy.
- the development of bio-processes and products combining ecological,
industrial and consumer advantages, particularly towards high
value-added products and processes for food, agro-industry and
(biochemical sectors, including fine chemicals, and in the fields of
biocatalysis, nanobiotechnology devices, and products derived from
improved plants and farm animals.
PRIORITIES FOR THE 1999 CALLS
The projects to be supported must address the link between the ability
to discover and the ability to exploit, through focusing on the
mobilisation of players from research, industry, and finance sectors. They
are expected to combine, as appropriate, innovative technologies with
bio-industries, SMEs and/or entrepreneurial initiatives, in order to both
develop RTD advances and exploit them to deliver bio-products and
processes. An important message to the applicants is that this key action
does not exclude basic research, nor focus only on applied research, but
should mobilise whatever scientific excellence, innovative technologies
and convincing exploitation strategies are needed for reaching the
socio-economic objectives and address the problem-solving approach of this
key action, as stated in the "Objectives and deliverables". In
view of those requirements, the projects can address a wide spectrum of
targets, provided they focus on the above requirements and on the
objectives of the key action. Consequently, the following RTD priorities
are illustrative examples which are not supposed to cover all potential
RTD activities to be implemented in this key action, and leave room for
innovative ideas from the applicants.
In particular
Key action 3 area 1 includes:
3.1.2. New and improved technologies for biological productions.
Aspects for consideration: improved technologies for the production of
health related substances, e.g. novel and safe animal cells-based
production systems for pharmaceutical substances including vaccine
production, novel plant-based production systems for pharmaceutical
substances.
Key action 3 Area 2. includes:
Energy - efficient bioremediation and waste biotreatment processes,
covering new bioprocesses for preventing industrial pollution, treating,
upgrading, and/or recycling of biological wastes and industrial
by-products. Aspects for consideration includes processes for preventing
pollution at the source, and the consumption of energy and raw material.
Emphasis will be given to develop new enzyme and industrial process
technologies exploiting modern biotechnology, e.g. the development of
novel biocatalysts or the design of micro-organisms to carry out
specific tasks. In addition, methodologies should be developed for
biotechnological processes and products and methods for waste water
treatment and water recycling.
3.2.4. Biodiversity and ecological dynamics of natural and introduced
populations includes, within the "Aspects for consideration",
methods and approaches to assessing the impacts of novel uses of
biodiversity, e.g. biofertilisers and biopesticides. Another
section covers transgenic plants resistant to phytopathogenic agents or
plants used for novel industrial uses.
3.2.5. Development of methods and strategies to ensure the safety of
new biomolecules or bioprocesses, and for the identification of
recombinant organisms and their residues in the environment and their
impact on human and animal health.
3.3. New biological and biotechnological processes and products from
cell factories, Exploiting the cellular and molecular characteristics of
organisms and the use of biological systems as tools in the
development of new products and technologies. Studies will be at the
level of molecules (e.g. biomolecules self assembly), the coupling of
molecules and cells to surfaces (e.g. control of interactions between
proteins and cells and surfaces) and the functional structures (e.g.
material processing technologies for nanofabrication).
3.3.2. High value-added products and processes involving/derived from
microorganisms, plants and animals, includes in the "Aspects for
consideration", development of more efficient fermentation,
biotransformation, and downstream processing as well as engineering
of the pathways of primary and secondary metabolites of plants of
economic importance including the cellular and organ optimisation of
compounds.
3.3.4. Identification and sustainable use of metabolic and genetic
diversity as a source of new valuable products, includes in "Aspects
for consideration", new or improved methods for screening of marine
and terrestrial organisms and molecular characterisation of wild and
domesticated populations, including unculturable microorganisms, to
identify useful products and genes for transgenic production systems.
See also:
Work Programme
Theme
1 Key action 5. - Sustainable agriculture, fisheries and forestry, and
integrated development for rural areas
Theme
1 Key action 5. Area 2 - biological materials for non-food uses
Theme
1 Key action 5. Area 3 - Forestry and the integrated forestry-wood chain
Theme
1 Key action 5. Area 1- New and sustainable systems of production


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FP5 - Fifth Framework Programme (1998-2002):
Quality of Life - 3. The Cell Factory
Item:
FP5 - Fifth Framework Programme (1998-2002)
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FP5 - QLK3-2000-00479:
An integrated approach towards removal by plants of toxic metals from polluted soils (METALLOPHYTES)
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Publications:
Cell Factory - Community funded projects
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QLK3-1999-00004:
Enhanced, intelligent processing of food and related wastes using thermo-philic populations (INTELLTHERMCONTROL)
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QLK3-1999-00034:
Polysaccharide molecular engineering - The use of mannuronan C-5 epimerases for the upgrading of alginates and heteromannuronans (POLYENG)
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QLK3-1999-00080:
Novel bioprocesses for hemicellulose up-grading (BIO-HUG)
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QLK3-1999-00089:
Upgrading of sugar beet pectins by enzymatic modification and molecular farming
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QLK3-1999-00097:
The use of mycorrhizal fungi in phytoremediation projects (MYCOREM)
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QLK3-1999-00104:
In vitro production of high quality mammalian oocytes for biotechnology, assisted reproduction, breeding and toxicology-teratology purposes
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QLK3-1999-00213:
Controlling fatty acid breakdown in order to produce viable oilseeds with increased yields of novel oils (CONSAB)
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QLK3-1999-00413:
Engineering of cellular quality control systems in Bacillus subtilis for the production of high value-added proteins
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QLK3-1999-00533:
Electric DNA chips for bioprocess control
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QLK3-1999-00590:
Fungal metalloenzymes oxidizing aromatic compounds of industrial interest (PELAS)
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QLK3-1999-00917:
Exploitation of a novel sec-independent secretion pathway for protein production
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QLK3-2000-00020:
A functional blueprint for the Zea mays endosperm cell factory
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QLK3-2000-00060:
An ecologically safe selection system for transgenic crops based on modified plant-tubulin genes (ECOTUB)
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QLK3-2000-00078:
Improvement of transgene expression and gene silencing in transgenic plants
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QLK3-2000-00103:
Optimising nutritional quality of crops
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QLK3-2000-00122:
Exploitation of Streptomyces protein secretion for robust biopharmaceutical bioprocess development
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QLK3-2000-00163:
Multifunctional permeable barriers carrying well-performing microbial biofilms for treatment of mixed pollutant plumes (MULTIBARRIER)
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QLK3-2000-00174:
Applications of nanobiotechnologies to yeast: optimisation of bioprocesses for products of industrial, medical, and agricultural importance
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QLK3-2000-00196:
Changing maize grain development to provide lines better adapted to the European agricultural and commercial environment
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QLK3-2000-00227:
The dynamic nature of introgressive hybridisation in natural and introduced polyploid plants from agricultural and riparian landscapes: An evaluation of molecular tools in willows
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QLK3-2000-00273:
Engineering of hybrid proteins containing cellulose-binding domains - Novel biotechnological tools for pulp, paper and textile industry
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QLK3-2000-00302:
Precise and efficient genetic improvement of cereal seeds
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QLK3-2000-00328:
Transcription factors controlling plant responses to environmental stress conditions
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QLK3-2000-00349:
Rational engineering of lipid metabolism in flax to produce branched-chain fatty acids, unusual fatty acids with potent biolubricant properties
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QLK3-2000-00361:
Virus-resistant transgenic plants: Ecological impact of gene flow (VRTP IMPACT)
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QLK3-2000-00362:
The potential and application of virus host evasion genes that modify apoptosis and cytokine responses
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QLK3-2000-00365:
Precision engineering of plant genes
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QLK3-2000-00426:
Engineering integrated biocatalysts for the production of chiral epoxides and other pharmaceutical intermediates (EPOX)
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QLK3-2000-00463:
New anti-inflammatory natural products from medicinal plants using inducible transcription factors and their signalling pathways as molecular targets
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QLK3-2000-00481:
Sensor arrays for environmental, generic and routine detection of pesticides
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QLK3-2000-00497:
Construction of Corynebacterium glutamicum strains producing either L-valine or D-pantothenic acid - A rational approach using genome research
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QLK3-2000-00547:
Effects and mechanisms of Bt transgenes on biodiversity of non-target insects: pollinators, herbivores and their natural enemies (Bt-BIONOTA)
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QLK3-2000-00640:
Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes
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QLK3-2000-00649:
The European Sulfolobus Project. Screening for and expressing thermostable enzymes of industrial interest from Sulfolobus and other Crenarchaeotes
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QLK3-2000-00725:
Industrial biocatalysis with new oxygenases in a novel electro-enzyme reactor
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QLK3-2000-00809:
PROduction of high value-added carotenoids and proVITamin A in cell factory crops (ProVitA)
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QLK3-2000-01068:
Genetic prospecting of biodiversity in geothermal habitats
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QLK3-2000-01079:
The European Wolbachia project: towards novel biotechnological approaches for control of arthropod pests and modification of beneficial arthropod species by endosymbiotic bacteria
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QLK3-2000-01481:
Intelligent signal processing of biosensor array using pattern recognition forcharacterisation of wastewater: aiming towards alarm systems (INTELLISENS)
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QLK3-2000-01528:
Biodiversity of methanotrophs and their bioremediation and biotechnological exploitation (BOMBBE)
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QLK3-2000-01537:
Exploiting yeast cell wall for high throughput screening of antimicrobial agents
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QLK3-2000-01598:
Impact of three selected biotechnological strategies for potato pathogen control on the indigenous soil microbiota (POTATOCONTROL)
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QLK3-2000-01678:
Exploration of genomic and metabolite diversity of a novel group of abundant soil bacteria
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QLK3-2000-01759:
Ecological and environmental biosafety assessment of novel plant and microbial biotechnology products (ECO-SAFE)
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QLK3-2000-40459:
Extraction and stabilisation of natural colours from renewable resources for use in non-food applications: cosmetics, textile and paints
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QLK3-2001-00101:
Testing integrated GM-Rhizoremediation systems for soil bioremediation (GM-Rhizoremediation)
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QLK3-2001-00149:
Combinatorial engineering of glycoside hydrolases from the alpha-amylase superfamily (CEGLYC)
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QLK3-2001-00278:
Sensing and controlling single molecules by novel electrical, mechanical and optical methods with applications to nanobiotechnology (NANOCELL)
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QLK3-2001-00403:
Whole-cell Baeyer-Villiger monooxygenase biocatalysts: Methodologies for exploitation (BIOMEX)
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QLK3-2001-00435:
Solvent tolerant bacteria allowing a broader performance of biotransformations of organic compounds in two phases (BARTOLO)
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QLK3-2001-00448:
Development of highly specific enzymes for genome manipulation (EnGeM)
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QLK3-2001-00519:
Directed evolution of enantioselective biocatalysts (EvoCatal)
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QLK3-2001-00533:
Engineering yeast for efficient expression of heterologous membrane transporters (EFFEXPORT)
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QLK3-2001-01586:
Novel bioinsecticides fom insect parasitoids
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QLK3-2001-01629:
Assembly and application of Photosystem II-based biosensors for large scale environmental screening of specific herbicides and heavy metals (BEEP)
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QLK3-2001-01657:
Analysis of geneflow from crop to wild forms in lettuce and chicory and its population-ecological consequences in the context of GM-crop biosafety (ANGEL)
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QLK3-2001-01676:
Novel bioreductions by hyperthermophilic microorganisms for the natural, specific and on-line production of fine chemicals
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QLK3-2001-01783:
Novel sources of actinomycete diversity for detection of antimicrobial agents with pharmaceutical applications
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QLK3-2001-02242:
Gene flow from transgenic plants: evaluation and biotechnology (TRANSBAC)
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QLK3-2001-02295:
Dynamics and composition of filamentous microorganism communities in industrial water systems (DYNAFILM)
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QLK3-2001-02400:
New products from starch-derived 1,5-Anhydro-D-Fructose (NEPSA)
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QLK3-2001-60077:
Quantitative characterisation of industrial microorganisms (QCIM)
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QLK3-2002-01923:
Biosensors for in situ evaluation of bioavailability of pollutants based on transcriptional regulators à la carte (BIOCARTE)
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QLK3-2002-01930:
Investigation of biochemical and genetical diversity of terpenoid biosynthesis for the production of high value-added compounds (INTESY)
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QLK3-2002-01938:
Phototrophic biofilms and their potential applications: Towards the development of a unifying concept (PHOBIA)
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QLK3-2002-01939:
Micro-arrays for the detection of the abundance and distribution of pathogenic protozoa, flagellated algae and diatoms (MICROPAD)
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QLK3-2002-01940:
Eukaryotic polyketides in surrogate hosts (EUKETIDES)
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QLK3-2002-01945:
Improving arable production systems by expressing marine algal rubisco in crop plants (MARISCO)
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QLK3-2002-01967:
Silicon biotechnology: Biofabrication of nanostructured silica and use of enzymes involved in metabolism of biogenic silica in industry and medicine (SILIBIOTEC)
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QLK3-2002-01969:
Protecting the benefits of Bt-toxins from insect resistance development by monitoring and management (ProBenBt)
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QLK3-2002-01972:
Multigenome access technology for industrial catalysts (MGAtech)
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QLK3-2002-01973:
Developing single nucleotide polymorphism (SNP) markers for adaptive variation in forest trees (TREESNIPS)
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QLK3-2002-02032:
Functional genomics and proteomics of Trichoderma antagonist strains for industry and agriculture (TRICHOEST)
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QLK3-2002-02035:
Compendium of Arabidopsis gene expression (CAGE)
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QLK3-2002-02038:
Demonstration of increased yield and productivity in selected commercial organisms by strategic transformation of key genes from Aspergillus niger (ANTICO)
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QLK3-2002-02056:
Gene mining of metagenomes for novel enzymes and therapeutics (Gemini)
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QLK3-2002-02063:
Development and risk assessment of a field-based portable biosensor using genetically-modified bioluminescent bacteria (BIOGEM)
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QLK3-2002-02068:
Soil meta-genomics to identify novel mechanisms of antagonism and antifungal activity for the improved control of phytopathogens (METACONTROL)
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QLK3-2002-02071:
DNA replication and biotechnological applications (REPBIOTECH)
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QLK3-2002-02086:
Exploiting the secretion machinery of Pseudomonas for the nanotechnological production of pharmaceuticals (NANOFOLDEX)
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QLK3-2002-02097:
Developing a genomic toolbox for exploring and exploiting bacterial biodiversity (BACDIVERS)
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QLK3-2002-02140:
Environmental impact assessment of transgenic grapevines and plums on the diversity and dynamics of virus populations (TRANSVIR)
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QLK3-2002-02141:
Development of a capacitance based immunodetection analyser for the assay of genetically modified organisms in foods (IMAGEMO)
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QLK3-2002-02151:
Ciliates as monitors for environmental safety of GMO (CIMES)